Slc22a14-deficient mice were born approximately at the expected ratio according to Mendel’s law (46 +/+, 105 +/− and 35 −/−) and no apparent abnormalities were observed in growth or behaviour, including alopecia; however, Slc22a14−/− male mice showed severe infertility (Table 1) despite that a vaginal plug was usually observed. This evidence concerns the gene SLC22A14 and Infertility.