APOB and obesity due to melanocortin 4 receptor deficiency: Because we found that the APOB C/T SNP at chr13:20932165 coding for glycine or aspartic acid was associated with multiple traits in addition to levels of serum LDL, the likelihood that these and potentially other variants in humans would culminate in up to one third of adult females being resistant to high fat diet induced obesity is both novel and of particular interest.