On the other hand, decrease in IL-8 (YI: 0.35; AUC: 0.66; P < 0.05) and increase in VEGF (YI: 0.33; AUC: 0.80; P < 0.0001) showed significant ability to diagnose cancer in COPD patients. This evidence concerns the gene VEGFA and chronic obstructive pulmonary disease.