Several in-vitro and in-vivo studies17, 24, 25, 26, 27 have applied 31P-NMR to measure phospholipid metabolite levels in tumour/cells responding to drugs targeting the PI3K/Akt/mTOR but the findings have not demonstrated a clear consensus especially with respect to their effects on PCho content. The gene discussed is MTOR; the disease is neoplasm.