The IL-10 rs1800871 C/T genotype correlated with better OS in low-grade glioma patients (adjusted HR = 0.736, 95% CI = 0.565–0.958, p = 0.022) and the PRKDC rs7003908 C/C genotype correlated with worse OS (adjusted HR = 4.288, 95% CI = 1.808–10.169, p = 0.001) and PFS (adjusted HR = 3.783, 95% CI = 1.601–8.943, p = 0.002) in high-grade glioma patients. Here, PRKDC is linked to glioma.