We also found that the PRKDC rs7003908 C/C genotype correlated with poor prognosis in high-grade glioma patients as measured by OS (3-year survival rate = 0.0%, median survival = 6 months, Log-rank p = 0.000, HR = 4.556, 95% CI = 1.936–10.721, p = 0.001) and PFS (3-year survival rate = 0.0%, median survival = 4 months, Log-rank p = 0.000, HR = 4.430, 95% CI = 1.884–10.416, p = 0.001), although this was not observed in low-grade glioma patients. The gene discussed is PRKDC; the disease is glioma.