Analogously, in gastrointestinal stromal tumors, Wiemer et al. [17] found in 2013 that overexpressing miR-222 significantly inhibits cellular proliferation, affects cell cycle kinetics and induces apoptosis by down-regulating its predicted target genes KIT and ETV1 in human gastrointestinal stromal tumors. This evidence concerns the gene ETV1 and gastrointestinal stromal tumor.