To test the potential pro-oncogenic role of Pygo2 in intestinal tumors, we first challenged constitutive, intestine specific Pygo2 deficient mice (“Pygo2−/−”; corresponding to the genotype VilCre; Pygo2 Δ/Δ) and control littermates (Pygo2lox(ex3)/lox(ex3)). This evidence concerns the gene PYGO2 and intestinal neoplasm.