We thank Drs. Norman Sharpless, Beverly Koller, Chuxia Deng, and Lothar Hennighausen for p16,Brca1 mutant and MMTV-cre mice, Ergonul A. Burcu for discussion on tumor pathology, the FACS core facility at University of Miami for cell sorting, the DVR core facility for animal husbandry. Here, CDKN2A is linked to neoplasm.