It is well documented that the expression of SPHK1 is higher in various types of human cancers, including gastric cancer, glioma, head and neck squamous cell carcinoma, prostate cancer, breast cancer, and non-Hodgkin lymphomas, and that its expression is associated with the development and progression of the disease [14]. This evidence concerns the gene SPHK1 and head and neck squamous cell carcinoma.