GBM is characterized by an amplification and/or mutation of wild-type epidermal growth factor receptor (EGFR), amplification of the platelet-derived growth factor (PDGF) and receptors (PDGFRα/β), mutations of the IDH1 and IDH2 genes or loss of tumor suppressor genes such as p53, PTEN or p16Ink4a. This evidence concerns the gene EGFR and glioblastoma.