IGHG3 and atherosclerosis: Under hyperlipidemic condition, signals driven by the intestinal microbiota via TLRs signaling pathway cause B2 cells in spleen to become functionally active and activated B cells then modify responses such as antigen presentation (upregulation of costimulatory molecules-MHC class II molecules) and antibody production (generation of active antibodies IgG and IgG3), thereby contributing to the development of atherosclerosis.