To gain further insight into the physiological function of the above four miRNAs in the resistance to F18 infection in pig intestinal tract, we predicted and screened out potential target mRNAs, including FUT2, DLG5, MUC4, TLR4, MyD88 and LBP. Coddens et al. demonstrated that the minimal binding epitope of the F18 receptor is the blood group H type 1 determinant (Fucalpha2Galbeta3GlcNAc), and FUT2 catalyzes the formation of blood group H type 1 [36]. This evidence concerns the gene TLR4 and infection.