The cytokine profile also confirmed that rTsPmy-pulsed DCs stimulated T. spiralis-infected mouse CD4+ cells to secrete IL-4, IL-10, TGF-β and IL-17A, but not IFN-γ, consistent with the Th2-skewed immune response induced by helminth infections [32]. The gene discussed is TGFB1; the disease is helminthiasis.