Similarly, loss of synapses is a major contributor to the cognitive impairments that is manifested in VaD, and temporal cortices from affected patients exhibit upregulation of the synaptic protein SNAP25 (synaptosomal-associated protein 25) [47], as well as significant accumulation of deamidated asparagine and glutamine residues in nerve terminal protein synapsin 1 compared with age-matched controls [51]. Here, SNAP25 is linked to Cognitive impairment.