This common set of leading edge genes included multiple genes implicated in the interrelated processes of DNA binding (LEF1, MLH1, RBM5, STAT1, CITED2, APLP2, DDX3Y, ZNF589), metal binding (MAN1A1, PRIM1, RBM5, STAT1, ZFP161, and ZNF589), apoptosis regulation (CITED2, MLH1, RBM5, STAT1), and cancer pathways (HSP90AA1, LEF1, MLH1, STAT1). The gene discussed is APLP2; the disease is cancer.