ACP1 interacts with many proteins implicated in tumor progression, including janus kinase [26], 31 β-catenin [27], and the ephrin A2 receptor (EPHA2, also implicated in our core network, [28]), among others, and ACP1 was one of eight genes whose combined expression in peripheral blood has been suggested as a predictive signature of stage I lung adenocarcinoma [29]. This evidence concerns the gene ACP1 and lung adenocarcinoma.