We used bio-informational predicting and found the let-7 might target IL-6, one of the most important inflammatory factors in the pathogenesis, growth and migration of CCA [40], and miR-372 and miR-373 might target CXCR4, a chemokine receptor involved in CCA progression and metastasis [41] (Fig. 3a). Here, CXCR4 is linked to cholangiocarcinoma.