Interestingly, further in depth analyses of T-bet and IFNγ expression in T cell subsets revealed a significant decrease in the CD45RA+ CD8+ T cell compartment (Tn and Temra) of myeloma patients, whereas expression in CD45RA− CD8+ T cells (Tcm and Tem) was similar in healthy and myeloma people (Fig. 2d). This evidence concerns the gene CD8A and plasma cell myeloma.