We included the following biomarkers: N-terminal pro-brain natriuretic peptide (NT-proBNP; myocardial stretch and neurohormonal activation), neprilysin (neurohormonal activation), galectin-3 (extracellular matrix), ST2 (inflammation, stretch, and extracellular matrix), high-sensitivity troponin T (hs-TnT; myocardial injury), cystatin-C (renal dysfunction), high-sensitivity C reactive protein (hs-CRP; inflammation), and soluble transferrin receptor (sTfR; oxidative stress). This evidence concerns the gene TFRC and Abnormal renal physiology.