The simultaneous up- and down-regulation of genes promoting neurodevelopment, including guidance cues (NTNG1, SLIT2, SEMA3E, and SEMA3G) and growth cone receptors (UNC5B, UNC5D, and PLXNB3) in the hsa04360:Axon guidance pathway, suggests iron deficiency resulted in altered hippocampal neurodevelopment. The gene discussed is PLXNB3; the disease is Iron deficiency anemia.