Notably, recent evidence suggests that miR-27b-3p enhances cytotoxicity of drugs by targeting inhibition of ENPP1, which induces ABCG2 expression and cell surface localization and increases drugs efflux.18 Therefore, we did not exclude the possibility that loss of miR-27b enhances breast cancer cells resistance to tamoxifen involved in downregulation of ABCG2 expression and activity. Here, ENPP1 is linked to breast carcinoma.