NR5A2, also known as LRH-1, a member of the nuclear receptor subfamily 5 has been implicated in the progression of breast cancer.31 Additionally, it has been reported that a high level of CREB1 is observed in breast cancer and associated with disease progression in breast cancer patients.32, 33 Our results also showed NR5A2 and CREB1 were highly expressed in the breast cancer tissues and inversely correlated to miR-27b-3p levels. Here, CREB1 is linked to breast cancer.