Cellular surface adherent CD44 molecule is a common CSC marker in several tumors and also a β-catenin-mediated transcriptional target.33, 34, 35 Our previous studies and other studies have demonstrated that CD44 is a potential NPC CSC marker.30, 31, 38, 52 The CD44 receptor primarily binds to hyaluronic acid, but it also serves as a serglycin receptor.18, 22, 23 However, so far it is unclear which downstream signaling pathways are activated by the serglycin–CD44 interaction. Here, SRGN is linked to nasopharyngeal carcinoma.