SRGN and neoplasm: In addition, when 2 × 102 cells were injected into nude mice, 50% of the mice (3/6) formed palpable tumors in the S18 scrambled cells group compared with no mice (0/6) in the S18 SG KD2 group, suggesting that serglycin level was associated with tumorigenesis or tumor-initiating capacity in vivo.