SRGN and nasopharyngeal carcinoma: Moreover, neutralizing treatment with an anti-serglycin blocking antibody did not affect S26 cell sphere formation but markedly decreased the number of S18 cell spheres, indicating that NPC CSCs produced abundant ECM serglycin proteoglycan to bind its cell surface adherent molecule CD44 receptor and maintained its self-renewal in an autocrine manner (Figure 5d).