CD44 and cancer: Wnt/β-catenin is an important and classical development signaling pathway in embryonic and CSCs and its hyperactivation is involved in the initiation and progression in the majority of malignancies.32 CD44 is a common CSC surface marker in subset of cancer and has a key role in their tumorigenesis.33 Previous investigations showed that CD44 was an activated β-catenin-dependent transcriptional target gene.34, 35 Therefore, we next investigated whether serglycin could induce β-catenin activation to mediate CD44 transcription.