CREM and heart failure: Several lines of evidence indicating that CHIP exerts its cardioprotective effect via regulating protein stability during heart failure.23, 25 CHIP-/- mice showed increased infarct size and myocyte apoptosis after cardiac ischemia, suggesting that this chaperone function may be involved in the cardioprotective effects of CHIP.24 Woo et al.25 found that CHIP prevented cardiomyocyte apoptosis and cardiac dysfunction via promoting ICER destabilization as part of the IGF-I survival signaling pathway.