Originally named DBC1 by mistake because its gene maps to a region of chromosome 8 that was found homozygously deleted in breast cancers,1 CCAR2 was instead upregulated in many types of tumors.1 These findings, together with the fact that CCAR2 loss in vitro prevents cancer cells growth6, 7 suggested for this protein a role of tumor promoter. The gene discussed is CCAR2; the disease is cancer.