To identify the mechanism responsible for the reduced proliferation of CCAR2-depleted cancer cells, we initially analyzed the levels of the apoptotic marker cleaved PARP, but no significant differences between control and CCAR2-depleted cells were found except for A549, where a slight increase of cleaved PARP levels was detectable in CCAR2 silenced cells (Figure 6a). The gene discussed is CCAR2; the disease is cancer.