PLD1 and neoplasm: It has been previously shown that autophagy provides FAs to maintain growth and survival of a dormant population of tumor cells.9, 38 Our data demonstrate that during prolonged glucose starvation, membrane phospholipids are the source of autophagy-derived FAs that support ATP synthesis and suppress excess ROS production in mitochondria; and this process is regulated by PLD1 (Figures 5 and 7).