Our data also support a previous finding that MDA-MB-231 cells are very sensitive to autophagy inhibition.39 In contrast, it was proposed by Jang et al.30 that the combination of PLD1 and autophagy inhibition might be of benefit to cancer patients, based on the result that PLD1 inhibition reduced cell viability in ATG7 knockdown MDA-MB-231 cells. This evidence concerns the gene PLD1 and cancer.