TGF-β signaling has been implicated in mammary gland morphogenesis and breast cancer.11, 12, 13 Notch and TGF pathways have similar patterns of expression and spatiotemporal regulation during development and recent reports suggest a direct link between them.14, 15 Notably, the endolysosomal pathway is crucial for the activation and degradation of Notch and TGF pathway mediators.16, 17. This evidence concerns the gene TGFB1 and breast cancer.