MMP3 and Alzheimer disease: Finally, it has also been described that intracerebral injection of LPS stimulates the expression of MMP-3 in brain tissue [21] and intracerebroventricular injection of Aβ1-42 oligomers, a validated Alzheimer’s disease mouse model characterized by a strong inflammatory response at the CPE and associated disruption of the BCSFB, revealed a marked upregulation of MMP-3 mRNA and protein expression in CPE cells [14].