While tumor-derived cell lines may retain the ability to respond to IFN-I and potent IFN-I inducers, like replicating Sendai virus (SeV) and the synthetic double stranded RNA (dsRNA) analog polyinosinic-polycytidylic acid (poly I:C), most do not mount an IFN-independent response to low-level infection. The gene discussed is IFNA1; the disease is neoplasm.