Amyloid beta (Aβ)-induced cell death was also counteracted by NGB overexpression by plasmid (pcDNA3-Ngb) transfection, as demonstrated by studies on PC12 cells [38] and, more recently, NGB has been shown to interact with heme-Aβ complexes known to catalyze oxidation of neurotransmitters and to have been associated with Alzheimer’s disease [39]. Here, NGB is linked to Alzheimer disease.