CASP3 and neuroblastoma: In neuroblastoma cells undergoing H2O2-induced apoptosis the upregulation of NGB by 17β-estradiol strongly increased the association between NGB and Cyt-C into the mitochondria and reduced Cyt-C and caspase-3 levels in the cytosol, demonstrating that the prevention of Cyt-C release is one of the pivotal mechanisms underlying NGB neuroprotection [100].