Marchal and colleagues explored the association between polymorphisms of MTHFR (rs1801133, rs1801131), MTR (rs1805087) and MTRR (rs1801394) genes and risk of PCa in a Spain cohort and found MTHFR rs1801131 is clearly related to prostatic carcinogenesis6. Here, MTRR is linked to posterior cortical atrophy.