The homozygous GG genotype of rs28372871 in the MTR gene promoter (crude OR = 1.44, 95% CI: 1.20–1.73, P = 3 × 10−4) and the homozygous AA genotype of rs1131450 in the 3′UTR of the MTR gene (crude OR = 1.77, 95% CI: 1.30–2.41, P = 2 × 10−4) were associated with a significantly increased risk of PCa compared with their respective homozygous wild-type genotypes. Here, MTR is linked to posterior cortical atrophy.