The multivariate logistic regression analyses revealed that the MTR rs28372871 GG genotype and rs1131450 AA genotype were associated with an increased risk of PCa, particularly in subgroups of Gleason score ≥8, positive extracapsular extension, positive seminal vesicle invasion and positive lymph node involvement in all three models, as supported by homogeneity tests (all P < 0.05). Here, MTR is linked to posterior cortical atrophy.