Collin et al.4 investigated the effect of eight single nucleotide polymorphisms (SNPs), including MTHFR rs1801133, MTHFR rs1801131, MTR rs1805087, MTRR rs1801394, MTHFD1 rs2236225, SLC19A1/RFC1 rs1051266, SHMT1 rs1979277 and FOLH1 rs202676, on PCa risk in a meta-analysis and found no significant effects of any SNPs on susceptibility to PCa. Here, MTR is linked to posterior cortical atrophy.