Epac1 is ubiquitously expressed and contributes to various pathologies, including cardiac hypertrophy, myocardial infarction, Alzheimer’s disease, chronic obstructive pulmonary disease, inflammation, diabetes, obesity, cancer, and pain3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15. The gene discussed is RAPGEF3; the disease is diabetes mellitus.