EGF and neoplasm: Frequently, tumor cells secrete pro-angiogenic molecules, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), angiopoietin (Ang)-1, transforming growth factor (TGF), tumor necrosis factor (TNF), and MMPs, thereby leading to activation of their receptors on the surface of ECs16, 17.