In addition, at 5 days post infection, the proportion of activated (CD44high/CD62Llow) CD4+ T and CD8+ T lymphocytes was augmented to 55.5% and 39.9%, when compared with 14.7% and 12.2% in uninfected controls or 27.8% and 10.2% in infected mice treated with E6446, respectively (Fig. 6c). This evidence concerns the gene CD4 and infection.