In RA synovial fibroblasts, FFAs dose-dependently enhanced the secretion of IL-6, IL-8, and monocyte chemoattractant protein 1 (MCP-1), as well as matrix metalloproteinase 1 (MMP1) and matrix metalloproteinase 3 (MMP3) [18]. The gene discussed is MMP3; the disease is rheumatoid arthritis.