Trazodone (serotonin antagonist/reuptake inhibitor, SARI) exerts its antidepressant effects through SERT inhibition, 5-HT2A/2C antagonism, and alpha2 adrenergic receptors antagonism; it also presents alpha1 adrenergic receptors antagonism (orthostatic hypotension), H1 antagonism (sedation and weight gain), and minimal anticholinergic effects [25]. Here, SLC6A4 is linked to orthostatic hypotension.