The main discoveries of the study are as follows: (1) exogenous rCTRP3 or Lenti-CTRP3 in ICH rats demonstrates the same tendency to attenuate ICH-induced brain injury; (2) CTRP3 promotes focal angiogenesis and attenuates ICH-induced brain edema and breakdown of the BBB; and (3) CTRP3 may exert its angiogenic effect through AMPK/HIF-1α/VEGF signaling. The gene discussed is HIF1A; the disease is injury.