PPARG and Alzheimer disease: Although PPAR gamma expression is high in AD, PPAR gamma agonists have been used in AD for both humans and animal models and have been shown to induce beneficial effects (Combs et al., 2000; Sastre et al., 2003; Camacho et al., 2004; D'Abramo et al., 2005; Pedersen et al., 2006; Risner et al., 2006; Escribano et al., 2010).