In AD, Wnt signaling activation induces neuroprotective effects via Wnt-3a (Alvarez et al., 2004), Wnt-5a, and Wnt-7a (Quintanilla et al., 2005), attenuates deleterious effects induced by Abeta, and facilitates the behavior of hippocampal neurons (Alvarez et al., 2004; Cerpa et al., 2010; Silva-Alvarez et al., 2013). Here, APP is linked to Alzheimer disease.