Neither ABIN1[D485N] × IRAK4[D329A] mice nor ABIN1[D485N] × IRAK1[D359A] mice developed splenomegaly (Fig. 5A) and, consistent with these observations, the levels of ANAs (Fig. 5B), dsDNA Abs (Fig. 5C), and other IgGs and IgM (Fig. 5D) in the serum of these mice were similar to WT mice. Here, IRAK4 is linked to Splenomegaly.