Moreover, no kidney inflammation was detectable in ABIN1[D485N] × IRAK4[D329A] mice or ABIN1[D485N] × IRAK1[D359A] mice at 6 mo of age (Fig. 6) (see Materials and Methods for scoring system), and the liver inflammation present in ABIN1[D485N]–knock-in mice was also largely reduced after crossing to IRAK4[D329A] or IRAK1[D359A] mice (Fig. 7B). The gene discussed is IRAK4; the disease is urogenital neoplasm.