Recent findings demonstrate that the overexpression of Jagged1, a major ligand of the Notch signaling pathway, ameliorates the dystrophic phenotype in the golden retriever muscular dystrophic dogs, which is an excellent model to the human dystrophynopathy, indicating that the Notch pathway can be considered a new therapeutic target in muscular dystrophies (Vieira et al, 2015). The gene discussed is JAG1; the disease is muscular dystrophy.