LAMB2 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: In contrast, other forms of dystroglycanopathy usually exhibit markedly diminished or no binding for both laminin and agrin in muscle, together with defective muscular basement membrane compaction (Michele et al, 2002; Hara et al, 2011; Willer et al, 2012; Goddeeris et al, 2013).