Several mouse models showed that DYRK1A knock-in could lead to neurodevelopmental delay, motor abnormalities, mental retardation, learning and memory deficits, and reduced neuronal density (3, –, 5), which could also be observed in DS patients (6, –, 8), indicating the important roles of DYRK1A in the development and functions of the nervous system. The gene discussed is DYRK1A; the disease is Dravet syndrome.