Studies showed that overexpression of DYRK1A could inhibit proliferation and promote cell cycle exit of NPCs by phosphorylation on several cell cycle regulators, including cyclin D1 (12, –, 14) and p27Kip (14, 15), which was consistent with the proliferative disruption of NPCs in DS. The gene discussed is DYRK1A; the disease is Dravet syndrome.