Mathematical modeling and in vivo experiments have suggested that most human G-CIMP− tumors may evolve from a common proneural-like glioma and indicated that gain of chromosome 7 and loss of chromosome 10 are common early events of gliomagenesis [4] PDGFA amplification was found to be the most likely initial driver of glioma formation, and sufficient for gliomagenesis in mice, but the potential contribution of other chromosome 7 genes to the initial oncogenic events are still unclear. The gene discussed is PDGFA; the disease is glioma.