To examine the effect of TRβ and NCoR in tumor lymphangiogenesis in vivo, we analyzed VEGF-C and VEGF-D gene expression as well as lymph vessel density in xenograft studies with MDA and MDA-TRβ cells transfected with siControl or siNCoR 72h before orthotopic inoculation into the fat mammary pad of nude mice. The gene discussed is NCOR1; the disease is neoplasm.