NCoR mRNA was significantly higher in the ER+ MCF-7 and ZR75–1 cells than in the very aggressive HCC-1954 cells and in the MDA-MB-231 cells, while VEGF-C and VEGF-D transcripts exhibited an opposite pattern, being lower in the ER+ positive cell lines (Figure 1A). The gene discussed is ESR1; the disease is hepatocellular carcinoma.