In the present study, we show that the corepressor NCoR and the nuclear receptor TRβ can inhibit transcription of the VEGF-C and VEGF-D genes, acting as potent repressors of tumor lymphangiogenesis in breast cancer xenograft models and correlating negatively with the expression of lymphangiogenic genes in human breast tumors. The gene discussed is VEGFD; the disease is neoplasm.