Our studies have shown that MM patient bone marrow mononuclear cells, when co-treated with an XPO1 inhibitor and PIs, synergistically induced apoptosis in MM cell populations but not in non-myeloma bone marrow cells, indicating that XPO1 inhibition may specifically inhibit cancer cells in MM patients [4, 5]. This evidence concerns the gene XPO1 and Miyoshi myopathy.