Apoptosis results (flow cytometry using activated caspase 3) from human PI-resistant and parental MM cells after 20-hour concurrent treatment with selinexor (300 nM) or KOS-2464 (10 nM) ± bortezomib (10 nM) or carfilzomib (20 nM) are shown in Figure 1. Here, CASP3 is linked to Miyoshi myopathy.