XPO1 and cancer: XPO1 inhibitors in human MM have been shown to inhibit the export of the following cancer-related proteins or mRNAs from the nucleus: c-myc, CDC25A, BRD4, p53, Mcl-1, BCl-xL, NFκB, p21, p27, IκB, FOXO3A, FOXO1A, PP2A, PUMA, BAX, CHOP, C1-0orf10, MIC1, IL-6, VEGF, MIP1ß, and IL-10 [5, 10, 15].