In particular, expression of the GAC transcript was significantly higher in AML with complex or del 5/7 cytogenetics (n=31) and in core-binding factor AML (representing t(8;21) and inv(16)) (CBF-AML, n=14) than in normal karyotype AML (n=88, p=0.0187 and 0.00184, respectively; Figure 1B). Here, GLS is linked to acute myeloid leukemia.