In a gene expression dataset of various AML subtypes (n = 529) described previously by Verhaak et al. [14], higher expression of GAC was confirmed in AML with t(8;21) (n=37, 1.27-fold, p=0.00077), FLT3-ITD AML (n=143, 1.25-fold, p=1.84×10−7) and interestingly AML with silenced CEBPA (unmutated, with decreased CEBPA mRNA levels [15]) (n=10, 1.7-fold, p=2.92×10−7) than in the remaining AML. Here, GLS is linked to acute myeloid leukemia.