IDH2 and acute myeloid leukemia: In mut-IDH1 or mut-IDH2 primary AML samples, CB-839 caused moderate reductions (range 12-58%, average 35.6±15.1%, p=0.015) in 2-HG levels (Figure 5A), in concert with expected decreases in concentrations of Glu, aspartate, malate, and GSH.