In turn, inhibition of GLS with CB-839 (1 μM) predominantly inhibited cellular growth (~40%) (Figure 2D), while induction of apoptosis was seen in some cell lines, such as NB4, Kasumi, KBM5, HL-60, and Myc-driven Burkitt lymphoma cell line Raji, used as a positive control (Figure 2E) Notably, GAC expression was elevated in Kasumi cells harboring t(8;21) and HL-60 AML cells with complex cytogenetics, exhibited higher apoptosis induction in response to CB-839. The gene discussed is GLS; the disease is acute myeloid leukemia.