Next we examined the effect of PRIMA-1Met on CRC cell growth, and the results showed that PRIMA-1Met inhibited the growth of three cell lines: TP53wt HCT116wt, TP53mut SW480, and TP53neg HCT116neg (Figure 1D), confirming that the inhibitory effect of PRIMA-1Met on CRC cell growth is independent of TP53 status. Here, TP53 is linked to colorectal carcinoma.