Additionally, these xenograft models suffer from 1) unknown effectiveness of human IFN in a mouse setting; 2) uncertain effects of mouse IFN on human xenografts; 3) an inability of murine cytokines to intercept the infection, favoring virus persistence; and 4) inefficient killing of human tumor cells such as SUM149 and DU145 by murine immune cells. The gene discussed is IFNA1; the disease is neoplasm.