RUNX2 and breast cancer: To further investigate the role of RUNX2 during CAF/BMP2-induced advantages of homing, residing and growing of breast cancer cells in the bone microenvironment, we assessed the chemotaxis, adhesion, anchorage-independent growth and proliferation of MCF-7 and T47D cells treated as detailed as above in MC3T3E1 cell- and MG-63 cell- mimic bone microenvironment.