RUNX2 and breast cancer: Thus, RUNX2 functions as a master mediator during the transformation of epithelial breast cancer cells into ostomimetic cells under CAF/BMP2 induction, and the expression of BRGs was repressed in the TGF-β/SMAD/RUNX2 signaling pathway, but induced in the BMP/SMAD/RUNX2 signaling pathway.