Compared with the NC group, overexpression of BX357664 could remarkably influence the expression of EMT markers in the protein level, leading to the upregulation of E-cadherin and the downregulation of N-cadherin and vimentin, which indicated that BX357664 could inhibit EMT in RCC cells (p < 0.05; Figure 4C). The gene discussed is CDH1; the disease is renal cell carcinoma.