Moreover, effector CD4+ T cells isolated from acute FV infection were transcriptionally distinct from typical exhausted CD4+ T cells isolated from chronic lymphocytic choriomeningitis virus (LCMV) infection (Crawford et al., 2014; Figure S13A), suggesting that expression of inhibitory receptors by FV-primed effector CD4+ T cells was part of acute effector differentiation rather than of the exhaustion that characterizes chronic viral infections. The gene discussed is CD4; the disease is viral infectious disease.