Using ZL55 mesothelioma cells, derived from an epithelial tumour biopsy of the pleural cavity of a 52-year old male, prior to treatment, with a known history of exposure to asbestos [23], we previously studied the cytotoxic effects of CDDP and highlighted the roles of PKC-δ and PKC-α: whilst PKC-δ is a pivotal portion of the apoptotic program, PKC-α mediates pro-survival effects [18]. This evidence concerns the gene PRKCA and mesothelioma.