In order to assess the discriminative potential of a single or a combination of any marker(s) in HA-PCOS, NA-PCOS and the non-PCOS group, we performed a hierarchical cluster analysis as described by van den Ham et al.[23] This analysis showed clustering of leptin, RBP-4, DPP-IV and adiponectin specific for HA-PCOS with a strong correlation of cases with increased BMI, as is depicted in Fig 1. This evidence concerns the gene LEP and polycystic ovary syndrome.