Adiponectin is secreted in adipose tissue and exerts anti-atherogenic, anti-inflammatory and insulin-sensitizing effects.[36] It has been shown that serum concentrations of this protein are inversely correlated to obesity, insulin resistance and diabetes mellitus type 2.[36,37] Circulating concentrations appear to be lower in women with PCOS compared to non-PCOS women, even after adjustment for BMI-related effects.[38]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.